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2025 ICD-10-CM code L51.2

Toxic epidermal necrolysis [Lyell]

Appropriate coding requires careful documentation of the extent of skin involvement to ensure accurate classification of the severity of TEN.Use additional codes to specify percentage of body surface area affected.

Modifiers may be applied to reflect the circumstances of the care provided, such as the place of service or the type of provider.

Medical necessity for treatment of TEN is established by the severity of the condition, the extent of skin involvement, and the need for intensive medical management to prevent life-threatening complications such as sepsis, dehydration, and multi-organ failure.

The clinical responsibility for managing TEN involves dermatologists, intensivists, and other specialists in burn care. Treatment focuses on supportive care, including fluid management, pain control, infection prevention, and nutritional support.

IMPORTANT L51 (Toxic epidermal necrolysis) excludes staphylococcal scalded skin syndrome (L00) and Ritter's disease (L00).Additional codes may be used to specify the percentage of skin exfoliation (L49.-).

In simple words: Toxic epidermal necrolysis (TEN), sometimes called Lyell syndrome, is a serious skin problem where the outer layer of skin peels off in large sheets. It's usually caused by a medicine or infection and needs urgent medical attention.

Toxic epidermal necrolysis (TEN), also known as Lyell syndrome, is a severe, life-threatening skin condition characterized by widespread detachment of the epidermis (outer layer of skin).It's a reaction typically triggered by medication or infection, resulting in extensive blistering and skin peeling.The condition requires intensive medical management, often involving supportive care in a burn unit.

Example 1: A 60-year-old female patient develops widespread blistering and skin peeling after starting a new antibiotic.She is diagnosed with TEN and admitted to a burn unit for intensive care., A 35-year-old male patient presents with extensive erythema, blistering, and desquamation following a viral infection.Laboratory tests confirm TEN, and he requires hospitalization and aggressive supportive treatment., A 22-year-old female develops toxic epidermal necrolysis after taking an over-the-counter medication.Early recognition and prompt treatment in a specialized burn center prevent complications and improve patient outcome.

Comprehensive documentation should include detailed history of the patient’s medications, allergies, and recent infections.The extent of skin involvement should be meticulously documented, along with laboratory results (e.g., complete blood count, electrolytes, liver function tests), and the response to treatment.Images of the skin lesions are beneficial.

** Accurate coding of TEN requires close attention to the clinical details of the case.The severity of TEN can vary, ranging from mild to life-threatening.Prompt diagnosis and treatment are crucial to improving patient outcomes.

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