2025 ICD-10-CM code M31.0
(Active) Effective Date: N/A Revision Date: N/A Deletion Date: N/A Systemic connective tissue disorders - Systemic connective tissue disorders (M30-M36) Diseases of the musculoskeletal system and connective tissue (M00-M99) Feed
Hypersensitivity angiitis, also known as leukocytoclastic vasculitis, is an inflammation of small blood vessels affecting multiple organs, caused by unknown factors or autoimmune responses.
Medical necessity for the diagnosis and treatment of hypersensitivity angiitis is established based on the presence of characteristic clinical manifestations and supportive laboratory and histopathological findings. The severity of the disease and potential for organ damage justify the use of immunosuppressive and anti-inflammatory therapies to reduce inflammation, prevent further organ damage, and improve patient outcomes.Treatment decisions are guided by clinical judgment and adherence to established clinical practice guidelines.
Diagnosis and management of hypersensitivity angiitis involves obtaining a comprehensive patient history, conducting a thorough physical examination (including palpation of affected areas), ordering and interpreting relevant laboratory tests (e.g., complete blood count, inflammatory markers, autoimmune antibodies), performing or interpreting tissue biopsies, and selecting and monitoring appropriate immunosuppressive and anti-inflammatory treatments.The physician's role also includes educating the patient about the disease, its management, and potential complications.
- Diseases of the musculoskeletal system and connective tissue (M00-M99)
- Systemic connective tissue disorders (M30-M36)
In simple words: Hypersensitivity angiitis is a condition where small blood vessels throughout the body become inflamed. This can happen due to an unknown reason, an overactive immune system, an allergic reaction, or exposure to certain substances. Symptoms may include purple skin spots, tiredness, fever, joint and muscle pain, weight loss, and weakness. Doctors diagnose it using tests like blood tests, biopsies, and physical exams. Treatment involves medicines to calm the immune system and reduce inflammation.
Hypersensitivity angiitis (M31.0) is a systemic vasculitis characterized by inflammation of small blood vessels, potentially impacting various organs.The etiology is often unknown, but it can be triggered by autoimmune responses, allergic reactions to medications, other diseases, or exposure to ingested or inhaled chemicals.Clinical manifestations include purpuric lesions (commonly on the lower extremities), fatigue, fever, arthralgia, myalgia, weight loss, and weakness. Diagnosis relies on patient history, physical examination (including palpation of affected areas), laboratory tests, tissue biopsy, and blood tests to identify underlying causes. Treatment typically involves immunosuppressive drugs (e.g., cyclophosphamide) and corticosteroids (e.g., prednisone) to manage inflammation.
Example 1: A 45-year-old female presents with palpable purpura on her lower extremities, fatigue, and arthralgias. Laboratory tests reveal elevated inflammatory markers and positive antineutrophil cytoplasmic antibodies (ANCA). A skin biopsy confirms leukocytoclastic vasculitis. The diagnosis of hypersensitivity angiitis is made, and treatment with corticosteroids and cyclophosphamide is initiated., A 60-year-old male with a history of hepatitis C develops rapidly progressive glomerulonephritis and hemoptysis.Tests reveal anti-glomerular basement membrane (anti-GBM) antibodies and the diagnosis of Goodpasture syndrome is confirmed.This would be coded under M31.0, but note that Goodpasture is not always hypersensitivity angiitis., A 30-year-old female presents with fever, fatigue, and widespread purpuric lesions.She reports recent exposure to a new medication.Laboratory tests show elevated inflammatory markers, and a skin biopsy confirms leukocytoclastic vasculitis.The medication is discontinued, and the patient is treated with corticosteroids.
Complete medical history including details about onset and progression of symptoms, any potential triggers (medications, infections, environmental exposures), presence of systemic symptoms (fever, fatigue, weight loss), and relevant past medical history.Detailed physical examination findings, including documentation of skin lesions (location, size, morphology), and assessment of organ involvement.Complete laboratory results (complete blood count, inflammatory markers, ANCA, autoimmune antibodies).Pathology report of the skin biopsy showing characteristic findings of leukocytoclastic vasculitis.Imaging studies (if performed) such as renal ultrasound, chest X-ray or CT scan to evaluate organ involvement. Treatment plan and response to therapy, including medication details, dosages, and any adverse effects.
** Goodpasture syndrome is a specific type of hypersensitivity angiitis that targets the glomerular basement membrane of the kidneys and the alveolar basement membrane of the lungs.While Goodpasture syndrome is often associated with M31.0, it's crucial to note that not all cases of hypersensitivity angiitis are Goodpasture syndrome. Careful clinical assessment and confirmatory laboratory testing are essential for accurate diagnosis and coding.
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- Specialties:Rheumatology, Nephrology, Pulmonology
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