2025 ICD-10-CM code N46.01
(Active) Effective Date: N/A Revision Date: N/A Deletion Date: N/A Diseases of the genitourinary system - Diseases of male genital organs (N40-N53) Diseases of the genitourinary system (N00-N99) Feed
Organic azoospermia; absence of sperm in semen due to testicular dysfunction.
ICD-10 codes do not utilize modifiers. Modifiers are associated with CPT/HCPCS codes.
Medical necessity for the diagnosis of azoospermia is established by the presence of infertility, with semen analysis demonstrating the absence of sperm. Further investigations, such as hormone testing and genetic testing, may be deemed medically necessary based on the clinical presentation and suspicion of underlying causes.
Urologist or reproductive endocrinologist.The physician is responsible for evaluating the patient's symptoms, ordering diagnostic tests to determine the underlying cause of azoospermia, and developing a treatment plan.
- Diseases of the genitourinary system (N00-N99)
- Diseases of the genitourinary system > Diseases of male genital organs > Azoospermia
In simple words: Organic azoospermia means a man's semen doesn't contain any sperm because his testicles aren't working properly to produce them. This is different from a blockage; the problem is with the sperm production itself.
Organic azoospermia (N46.01) is a condition characterized by the complete absence of sperm in the ejaculate (semen) resulting from impaired sperm production within the testicles.This is a type of non-obstructive azoospermia, meaning there is no blockage in the reproductive tract preventing sperm from reaching the ejaculate.The underlying cause is a problem with the testicles themselves, affecting their ability to produce functional sperm. This can stem from various factors, including genetic disorders, hormonal imbalances, previous trauma or injury, or other underlying medical conditions.
Example 1: A 35-year-old male presents with infertility. Semen analysis reveals azoospermia.Further testing reveals a genetic disorder affecting sperm production. Code N46.01 is used, along with additional codes to reflect the specific genetic condition., A 40-year-old male with a history of chemotherapy for cancer presents with infertility. Semen analysis confirms azoospermia.The physician documents that the azoospermia is likely due to chemotherapy-induced damage to the testicles. Code N46.01 is used along with codes specifying the history of cancer and chemotherapy., A 28-year-old male presents for infertility evaluation. Semen analysis reveals azoospermia.Hormonal testing shows low testosterone levels and elevated FSH levels, indicative of primary testicular failure. Code N46.01 is used, along with additional codes to specify the hormonal abnormalities.
* Complete patient history, including details of past medical conditions, surgeries, medications, and exposures to toxins.* Physical examination findings, including assessment of the testicles and reproductive organs.* Results of semen analysis showing complete absence of sperm.* Hormonal testing results (testosterone, FSH, LH).* Genetic testing results (if performed).* Imaging studies (if performed), such as ultrasound of the testicles.
** This code is used for the diagnosis of organic azoospermia.Additional codes should be used to identify the underlying etiology of the condition if known.The diagnosis of azoospermia requires a semen analysis performed by a qualified laboratory.
- Revenue Code: Refer to the specific payer's revenue code guidelines for appropriate assignment. Revenue codes vary depending on the healthcare setting and the services provided.
- RVU: RVUs are not directly assigned to ICD-10 codes. Reimbursement is determined by the procedures performed and related CPT/HCPCS codes, along with modifiers, place of service, and payer-specific fee schedules.
- Global Days: Not applicable to ICD-10 codes. Global surgical periods are associated with CPT codes for surgical procedures.
- Payment Status: Active
- Modifier TC rule: Not applicable to ICD-10 codes.
- Fee Schedule: Not applicable to ICD-10 codes. Fee schedules are determined by payers and are associated with CPT/HCPCS codes.
- Specialties:Urology, Reproductive Endocrinology, Endocrinology
- Place of Service:Office, Outpatient clinic, Hospital