2025 ICD-10-CM code N46.021
(Active) Effective Date: N/A Revision Date: N/A Deletion Date: N/A Diseases of male genital organs - Azoospermia due to extratesticular causes Diseases of the genitourinary system (N00-N99) Feed
Azoospermia due to drug therapy; absence of sperm in semen due to medication.
Modifiers may be applicable depending on the circumstances of the encounter (e.g., place of service, type of service). Consult the official modifier guidelines for details.
Medical necessity is established by the presence of infertility, confirmed by semen analysis, and a documented link between the drug therapy and the azoospermia. The physician should document the clinical findings and the reasons for suspecting a medication-induced etiology.If there is no other identifiable cause for the azoospermia, the medication-induced azoospermia should be considered the primary diagnosis.
Urologist or fertility specialist.The clinical responsibility involves evaluating the patient's history of medication use, conducting semen analysis to confirm azoospermia, and investigating potential underlying causes linked to the drug therapy.Management may involve medication adjustments, monitoring, or referral to a reproductive endocrinologist for further assessment and treatment options.Counseling on infertility and assisted reproductive technologies may also be a part of the clinical responsibility.
- Diseases of the genitourinary system (N00-N99)
- N46 (Male infertility) > N46.0 (Azoospermia) > N46.02 (Azoospermia due to extratesticular causes) > N46.021 (Azoospermia due to drug therapy)
In simple words: This code means a man's semen has no sperm because of a medicine he's taking.
N46.021, Azoospermia due to drug therapy, is an ICD-10-CM code that classifies the absence of sperm in the semen (azoospermia) as a direct result of medication or drug therapy.This condition is categorized under diseases of the male genital organs and specifically indicates that the cause is extratesticular, meaning it originates outside the testes.
Example 1: A 35-year-old male presents with infertility.He reports taking a specific medication for a chronic condition. Semen analysis reveals azoospermia.A review of his medication history indicates a strong correlation between the drug and the absence of sperm.N46.021 is the appropriate code., A 40-year-old male, undergoing chemotherapy for cancer, experiences azoospermia as a side effect of the treatment. The oncologist confirms that the medication is the likely cause.N46.021 is utilized, along with codes related to his cancer diagnosis and treatment., A 28-year-old male taking immunosuppressants post-organ transplant is found to have azoospermia upon fertility testing. His physician documents the association of the immunosuppressant with the absence of sperm. The code N46.021 is applied.
Complete patient history detailing all medications, including dosage and duration.Semen analysis report confirming the absence of sperm.Physician documentation establishing a causal relationship between the medication and azoospermia.
** This code is specific to azoospermia caused by drug therapy.Other codes exist for azoospermia due to other causes.Accurate coding relies on precise documentation supporting the direct causal relationship between the medication and the absence of sperm.
- Payment Status: Active
- Specialties:Urology, Endocrinology, Reproductive Endocrinology and Infertility
- Place of Service:Office, Hospital, Outpatient clinic