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2025 ICD-10-CM code N88.0

Leukoplakia of cervix uteri

Code N88.0 should be used when leukoplakia of the cervix uteri is confirmed by clinical examination and/or biopsy. Do not use this code if the leukoplakia is associated with other conditions like inflammatory diseases or polyps of the cervix, as those have separate codes.

Medical necessity is established by the presence of leukoplakia on the cervix, particularly within the transformation zone. Further investigation, including biopsy, is medically necessary to rule out precancerous or cancerous changes. Treatment is necessary if high-grade CIN or cancer is diagnosed.

Diagnosis and management of leukoplakia of the cervix usually falls under the purview of gynecologists or obstetrician-gynecologists. They are responsible for performing the necessary examinations (including visual inspection with acetic acid and colposcopy) and biopsies to determine the underlying cause and severity of the condition. They also determine the appropriate treatment plan, which may range from watchful waiting to surgical excision or other interventions.

In simple words: Leukoplakia of the cervix is a white patch on the cervix. It's often harmless but can sometimes be related to more serious conditions.

A white patch or plaque on the cervix, visible even before the application of acetic acid. It's caused by a buildup of keratin on the surface of the cervical epithelium. While it can be caused by chronic irritation or HPV infection, it can also be a sign of high-grade precancerous lesions or even invasive cancer.

Example 1: A 30-year-old female presents for a routine pelvic exam. During the speculum exam, a white patch is noted on the cervix. The area is biopsied, and the pathology report confirms leukoplakia without evidence of dysplasia., A 45-year-old female with a history of HPV infection undergoes a colposcopy. Leukoplakia is visualized within the transformation zone, and a biopsy reveals high-grade cervical intraepithelial neoplasia (CIN)., A 60-year-old female with postmenopausal bleeding undergoes a pelvic exam, revealing a white, thickened area on the cervix. A biopsy confirms leukoplakia with underlying invasive squamous cell carcinoma.

Documentation should include the location, size, and appearance of the leukoplakia. Results of any diagnostic procedures such as colposcopy, biopsy, and pathology reports are crucial. Any associated symptoms or risk factors, such as HPV infection or history of abnormal Pap smears, should also be documented.

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