In simple words: A newborn's blood cells are attacked by antibodies from the mother, which can occur if the mother and baby have incompatible blood types. This can cause the baby to have fewer red blood cells and lead to health issues.

This condition occurs when a mother's blood type is incompatible with her newborn's, leading to the production of antibodies that target the infant's red blood cells.This can result in the destruction of these cells, potentially causing anemia and jaundice.

Example 1: A newborn with blood type A is born to a mother with blood type O. The mother's antibodies cross the placenta and attack the infant's type A red blood cells. The infant develops jaundice and requires phototherapy., A newborn presents with prolonged neonatal jaundice. Blood tests reveal ABO incompatibility with the mother, confirming ABO isoimmunization as the cause of the hyperbilirubinemia., An infant born to a mother with a history of prior pregnancies with ABO incompatibility is closely monitored for signs of hemolytic disease.Despite preventive measures, the infant develops mild anemia due to ABO isoimmunization.

Documentation should include maternal and infant blood types, results of Coombs tests (direct and indirect), bilirubin levels, any treatment provided (e.g., phototherapy, exchange transfusion), and the infant's response to treatment.