2025 ICD-10-CM code Q98.7
(Active) Effective Date: N/A Revision Date: N/A Deletion Date: N/A Congenital malformations - Chromosomal abnormalities, not elsewhere classified (Q90-Q99) Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) Feed
Male with sex chromosome mosaicism.
Medical necessity is established through the presence of clinical manifestations associated with the sex chromosome mosaicism. The specific criteria for medical necessity will vary based on the associated symptoms and complications, such as ambiguous genitalia, developmental delays, learning difficulties, infertility, or hormonal imbalances.Documentation supporting the diagnosis and the need for further evaluation and management is crucial.
The clinical responsibility for a patient with Q98.7 involves a multidisciplinary approach, often including genetic counselors, endocrinologists, and other specialists depending on the associated clinical features.The physician's role encompasses the comprehensive evaluation of the patient, including a detailed history, physical examination, genetic testing (karyotyping or chromosomal microarray), and management of any related health issues.
- Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- Q98 Other sex chromosome abnormalities, male phenotype, not elsewhere classified
In simple words: This code describes a genetic condition in a male where there's a mix of different genetic material in his cells, specifically related to the sex chromosomes (X and Y chromosomes).This mix can lead to various physical characteristics or health issues, with the severity differing greatly from person to person.
This ICD-10-CM code signifies a male individual exhibiting mosaicism involving sex chromosomes.Mosaicism refers to the presence of two or more genetically distinct cell lines within an individual, originating from a single zygote. In this specific case, the mosaicism affects the sex chromosomes, resulting in a male phenotype despite the presence of variations in the sex chromosome complement across different cells.This condition can manifest with a range of clinical features, varying significantly in severity depending on the specific chromosomal pattern and the proportion of affected cells.
Example 1: A newborn male infant is found to have ambiguous genitalia and some minor developmental delays.Karyotyping reveals a sex chromosome mosaicism (e.g., 46,XY/47,XXY), leading to the assignment of code Q98.7. Further investigations are necessary to determine the extent of associated anomalies., A 15-year-old male presents with infertility and gynecomastia (breast development).Genetic testing confirms the presence of sex chromosome mosaicism (e.g., 46,XY/45,X), explaining the clinical presentation. Code Q98.7 is assigned, and the patient undergoes counseling and hormonal management., An adult male patient is being evaluated for an infertility workup.As part of the investigation, genetic analysis reveals a sex chromosome mosaicism. This is coded as Q98.7, and further genetic studies are necessary to establish the exact composition of the mosaicism and understand the implications for fertility.
Detailed patient history, including family history of genetic disorders. Physical examination findings, specifically noting any abnormalities. Results of chromosomal analysis (karyotype or microarray) specifying the mosaicism pattern.Relevant laboratory results, including hormonal assays and other investigations addressing the specific clinical concerns.Genetic counseling notes documenting discussions with the patient and family regarding diagnosis and management.All relevant imaging studies, such as ultrasound or MRI, if performed to address the clinical concerns.
** This code is used for males with sex chromosome mosaicism, and the associated clinical manifestations and their severity vary considerably depending on the specific mosaicism pattern. The clinical management should always address the individual's specific needs and symptoms.
- Payment Status: Active
- Specialties:Genetics, Endocrinology, Urology
- Place of Service:Office, Hospital, Genetics Clinic