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2025 ICD-10-CM code R25.3

Fasciculation. Twitching.

Code R25.3 is used to report fasciculation as a symptom or sign.It should not be used if a definitive diagnosis has been established.Refer to the Alphabetical Index to determine which symptoms and signs are to be allocated to Chapter 18 and which to other chapters.

Medical necessity for the evaluation and management of fasciculations is based on the underlying condition.If fasciculations are associated with other neurological symptoms, further investigation may be necessary to determine the cause and appropriate treatment.

In simple words: Muscle twitching.

Fasciculation refers to a small, local, involuntary muscle contraction and relaxation which may be visible under the skin.It is a symptom of several different conditions, including amyotrophic lateral sclerosis (ALS), but can also occur normally. Twitching is the most common lay term used to describe fasciculation.

Example 1: A 45-year-old male presents to his physician complaining of muscle twitching in his left arm. After a thorough examination and workup, including electromyography (EMG), the physician diagnoses the patient with benign fasciculation syndrome., A 60-year-old female presents to the emergency room with sudden onset of slurred speech and difficulty swallowing. Upon examination, the physician notes fasciculations in the tongue and upper extremities. After further testing, the patient is diagnosed with amyotrophic lateral sclerosis (ALS)., A 25-year-old female presents to her physician complaining of intermittent muscle twitching throughout her body, particularly in her eyelids and calves. She reports increased stress and anxiety lately. After a physical examination and review of her medical history, the physician attributes the fasciculations to anxiety and caffeine intake.

Detailed documentation of the location, frequency, and duration of fasciculations. Associated symptoms such as muscle weakness, atrophy, or sensory changes should also be documented. Results of any diagnostic tests, such as electromyography (EMG) or nerve conduction studies, should be included.

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