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2025 ICD-10-CM code R50.84

Febrile nonhemolytic transfusion reaction (FNHTR).Post-transfusion fever.

Code first the underlying condition if the fever is associated with conditions like leukemia, neutropenia or sickle-cell disease.

The medical necessity of treating an FNHTR is established by the presence of a fever and other symptoms temporally related to a blood transfusion, with other serious causes ruled out.

Diagnosis and management of the reaction, including stopping the transfusion, administering antipyretics, and monitoring vital signs.

In simple words: A fever that develops after a blood transfusion, but is not caused by the red blood cells being destroyed.

Febrile nonhemolytic transfusion reaction (FNHTR). Post-transfusion fever.

Example 1: A patient receiving a blood transfusion develops a fever of 101°F. Other symptoms are mild, and the reaction is managed by stopping the transfusion and administering antipyretics., A patient with a history of multiple transfusions experiences a fever during their current transfusion.The fever is determined to be an FNHTR and managed accordingly., A patient develops chills and a fever within a few hours after a blood transfusion.Lab tests rule out hemolysis and other causes, confirming FNHTR.

Signs and symptoms of the fever, temporal relationship to the transfusion, other potential causes ruled out, treatment provided.

** Excludes1: chills without fever (R68.83), febrile convulsions (R56.0-), fever of unknown origin during labor (O75.2), fever of unknown origin in newborn (P81.9), hypothermia due to illness (R68.0), malignant hyperthermia due to anesthesia (T88.3), puerperal pyrexia NOS (O86.4).

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