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2025 ICD-10-CM code R87.621

Atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion on a vaginal cytologic smear (ASC-H).

Follow current ICD-10-CM coding guidelines.Appropriate use of additional codes as needed to accurately reflect the clinical findings.

Medical necessity is established when a Pap smear reveals atypical squamous cells that cannot rule out HSIL, necessitating further evaluation and management to detect and treat precancerous or cancerous lesions.

Obstetrician-gynecologist, pathologist

IMPORTANT Related codes include R87.620 (ASC-US), R87.622 (LGSIL), R87.623 (HGSIL), and R87.624 (cytologic evidence of malignancy).Consider using additional codes to specify acquired absence of the uterus and cervix (Z90.71-).

In simple words: The Pap smear showed some unusual cells in the vagina.More tests are needed to see if these cells are harmless or if there is a problem.

This code signifies the presence of atypical squamous cells on a Pap smear from the vagina, where the cellular abnormalities cannot be definitively classified as benign or indicative of a high-grade squamous intraepithelial lesion (HSIL).Further investigation is usually required to determine the exact nature of the cellular changes.

Example 1: A 35-year-old female presents for a routine Pap smear.The results reveal atypical squamous cells, and further testing is recommended to rule out HSIL., A 48-year-old woman with a history of abnormal Pap smears has a follow-up Pap smear which shows atypical squamous cells that cannot rule out high-grade squamous intraepithelial lesion (ASC-H). Colposcopy and biopsy are recommended., A 22-year-old sexually active female undergoes a Pap smear as part of a well-woman exam. The results show ASC-H on the vaginal smear.Further testing, including HPV testing, is needed.

Complete patient history, including age, sexual history, and relevant medical conditions. Results of the Pap smear with detailed microscopic description of the cellular abnormalities. Results of any additional testing, such as HPV testing, colposcopy findings, and biopsy results.Physician's interpretation and diagnostic reasoning documented in the medical record.

** This code is used for abnormal cytological findings on a vaginal smear only.For abnormal cervical findings use codes in the R87.61 series.

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