In simple words: This code indicates a lasting health issue that resulted from a bad reaction to certain female hormones (estrogens and progestogens, not including the ones used for birth control).

Adverse effect of other estrogens and progestogens, sequela. This code represents the long-term consequences or after-effects resulting from an adverse reaction to estrogens and progestogens, excluding those specifically classified elsewhere.

Example 1: A patient experiences long-term bone loss (osteoporosis) following prolonged use of certain estrogens for hormone replacement therapy. The osteoporosis is a sequela of the adverse effects of the estrogen., A patient develops a persistent skin rash (dermatitis) after taking a progestogen medication. The dermatitis remains even after discontinuing the medication and is considered a sequela of the adverse drug effect., A patient experiences persistent blood clots as a sequela following treatment with a specific type of estrogen. The provider must document the relationship between the estrogen use and the ongoing blood clotting issues.

Documentation should include the specific estrogen or progestogen involved, the initial adverse reaction experienced, the date of the initial reaction, the nature of the current sequela, and evidence supporting the causal relationship between the medication and the sequela.

** For accurate coding, distinguish between the initial adverse effect and the subsequent sequela. Code the current manifestation of the sequela. This code excludes birth trauma (P10-P15) and obstetric trauma (O70-O71). It also excludes mineralocorticoids and their antagonists (T50.0-), oxytocic hormones (T48.0-), and parathyroid hormones and derivatives (T50.9-).