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2025 ICD-10-CM code T45.1X5

Adverse effect of antineoplastic and immunosuppressive drugs.

Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate the cause of injury.

Yes, the 7th character is required to specify the encounter type (e.g., initial encounter, subsequent encounter, sequela).

Medical necessity for the use of antineoplastic or immunosuppressive drugs should be documented based on the patient's underlying condition and the clinical guidelines for managing that condition. The occurrence of an adverse effect may necessitate changes in medication or supportive care, which should also be documented.

The clinician is responsible for accurately documenting the adverse effect, identifying the causative antineoplastic or immunosuppressive drug, and providing appropriate management of the adverse effect.

In simple words: This code represents a harmful side effect from taking cancer or immune-suppressing medications.

Adverse effect of antineoplastic and immunosuppressive drugs. This code is used to document the harmful effects resulting from the administration of medications used to treat cancer or suppress the immune system.

Example 1: A patient receiving chemotherapy for breast cancer develops severe neutropenia (low white blood cell count) as a side effect of the treatment. The code T45.1X5 would be used to document this adverse effect., A patient undergoing a kidney transplant develops an infection due to the immunosuppressive drugs they are taking to prevent organ rejection. T45.1X5 would be used to document the adverse effect of the immunosuppressive drug., A patient with rheumatoid arthritis experiences nausea and vomiting as a side effect of their immunosuppressive medication. The code T45.1X5 is used to document these adverse effects.

Documentation should clearly specify the adverse effect experienced, the specific antineoplastic or immunosuppressive drug causing the effect, the severity and duration of the adverse effect, and any interventions or treatments provided.

** Excludes1: poisoning by, adverse effect of and underdosing of tamoxifen (T38.6). Additional codes may be needed to fully describe the specific adverse effect, such as anemia, neutropenia, or infection.

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