2025 ICD-10-CM code Z22.7

Latent tuberculosis infection (LTBI).

A Z code should not be used as a primary diagnosis if an active condition is present. If a procedure is performed, a corresponding procedure code must accompany the Z code.

Medical necessity for LTBI treatment is based on the risk of progression to active TB disease.Factors influencing this risk include the individual's immune status, age, and presence of other medical conditions.

Clinicians are responsible for screening individuals at risk for LTBI, interpreting diagnostic test results, and providing appropriate treatment and education to prevent progression to active TB disease.

In simple words: Latent TB means you have the bacteria that causes TB in your body, but it's not making you sick right now and you can't spread it to others.It's important to get treatment to prevent it from becoming active TB disease later.

Latent tuberculosis, also known as latent tuberculosis infection (LTBI), is a state where a person is infected with Mycobacterium tuberculosis but does not have active tuberculosis (TB) disease.Individuals with LTBI are asymptomatic, cannot spread the infection, and typically have a normal chest x-ray and negative sputum cultures. However, they have a risk of developing active TB disease in the future, particularly if their immune system becomes compromised.

Example 1: A healthcare worker with a history of recent exposure to a patient with active pulmonary TB has a positive tuberculin skin test (TST) but no symptoms of TB disease.The chest x-ray is normal. The Z22.7 code is used to document the LTBI., An immigrant from a high TB burden country presents for a routine health check-up. They are asymptomatic but have a positive interferon-gamma release assay (IGRA) blood test for TB. A chest x-ray is normal. The Z22.7 code is assigned to indicate LTBI., A patient with HIV undergoes routine TB screening and receives a positive TST result.They deny any symptoms of TB and have a normal chest x-ray. The Z22.7 code is used to document their LTBI status.

Documentation should include risk factors for TB exposure, results of TST or IGRA, chest x-ray findings, and any other relevant clinical information.

** Excludes1: nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis (R76.12) nonspecific reaction to tuberculin skin test without active tuberculosis (R76.11)

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