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2025 CPT code 0044U

Tick-borne relapsing fever (TBRF) Borrelia group, antibody detection to 4 recombinant protein groups, by immunoblot, IgG.

This code is for the IGeneX Tick-Borne Relapsing Fever (TBRF) Borrelia ImmunoBlots IgG test. It should not be used for other Borrelia tests or combined with other CPT codes for the same test.

Modifiers may be applicable depending on the specific circumstances of the test (e.g., modifier 91 for repeat testing).

Medical necessity for this test is established by the presence of signs, symptoms, or risk factors suggestive of Lyme disease or tick-borne relapsing fever.

The clinician orders the test, interprets the results, and makes treatment decisions based on the findings and the patient's clinical presentation.

In simple words: This test checks for Lyme disease by looking for specific markers (IgG antibodies) in your blood that show if your body has fought off the infection.

This test detects IgG antibodies to four species of Borrelia, the tick-borne bacteria that causes Lyme disease, using immunoblot analysis of four recombinant protein groups.

Example 1: A patient presents with symptoms suggestive of Lyme disease, such as fever, fatigue, and joint pain. The physician orders this test to check for IgG antibodies, which indicate past exposure to Borrelia., A patient previously treated for Lyme disease experiences recurrent symptoms. This test can help determine if the current symptoms are due to a reinfection or post-treatment Lyme disease syndrome., A patient has a history of tick bites and develops flu-like symptoms. This test can help differentiate Lyme disease from other tick-borne illnesses or viral infections.

The documentation should include the reason for testing (e.g., symptoms, exposure history), the date of the test, and the result.

** This code represents a proprietary laboratory analysis (PLA) and is not a Category I CPT code. 

** Only Enterprise users with EHR integration can access case-specific answers. Click here to request access.

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