2025 CPT code 0254U
(Active) Effective Date: N/A Revision Date: N/A Reproductive Medicine - Preimplantation Genetic Testing Proprietary Laboratory Analyses Feed
This CPT code reports the SMART PGT-A test, a next-generation sequencing (NGS) analysis of an embryo biopsy for chromosomal abnormalities (aneuploidy) and mitochondrial DNA scoring, aiding embryo selection in IVF.
Modifiers may apply depending on the circumstances of service. Consult the AMA CPT manual for appropriate modifier usage.
Medical necessity for 0254U is established when a patient is undergoing IVF and there is a clinical indication for preimplantation genetic testing to increase the likelihood of a successful pregnancy by screening for chromosomal abnormalities in embryos and improving embryo selection. This is often indicated by factors such as advanced maternal age, recurrent miscarriage, recurrent implantation failure, or severe male factor infertility.
The clinical laboratory analyst performs the test. The ordering physician is responsible for interpreting results in the context of the patient's clinical presentation and making decisions regarding IVF treatment.
In simple words: This lab test checks a tiny sample of an embryo for chromosome problems before it's put back in the mother's uterus during IVF. It uses advanced technology to identify any missing or extra chromosomes, helping doctors choose the healthiest embryo for implantation, leading to higher chances of a successful pregnancy.
CPT code 0254U represents the SMART PGT-A (Preimplantation Genetic Testing for Aneuploidy) test from Igenomix® USA.This test uses next-generation sequencing (NGS) and mitochondrial DNA scoring (MitoScore) to analyze a trophectoderm biopsy for chromosomal abnormalities (aneuploidy), including monosomy, trisomy, segmental aneuploidies (partial deletions/duplications), and mosaicism.The MitoScore indicates embryo energy status. Results help select embryos for transfer during in vitro fertilization (IVF), aiming to increase pregnancy rates and decrease miscarriage risk. The analysis encompasses all necessary steps from cell lysis to detection.Prior procedures like microdissection (CPT codes 88380 and 88381) may be reported separately.
Example 1: A 38-year-old woman undergoing IVF due to advanced maternal age has multiple embryos created.The 0254U test is ordered to screen for aneuploidy to select the healthiest embryo for transfer., A couple experiences recurrent IVF implantation failure.0254U testing is implemented to assess embryo ploidy, aiming to improve implantation success rates., A patient with a history of recurrent miscarriage is undergoing IVF. The 0254U test is used to improve the chance of a successful pregnancy by selecting genetically normal embryos and increase the pregnancy chances.
* Patient demographics and medical history, including reason for IVF and prior pregnancy outcomes.* Detailed IVF treatment cycle documentation, including stimulation protocol, egg retrieval, fertilization, and embryo culture methods.* Complete laboratory report for the 0254U test, including NGS data and MitoScore results.* Documentation supporting the selection of the embryo(s) transferred, including physician's interpretation of test results and rationale for embryo selection.* Consent forms signed by the patient.
** The test requires specialized expertise and equipment, and only certain laboratories may offer the SMART PGT-A test.Ensure compliance with all applicable regulations and guidelines related to IVF and genetic testing.
- Payment Status: Active
- Specialties:Reproductive Endocrinology and Infertility, Genetics
- Place of Service:Clinical Laboratory