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BETA v.3.0

2025 CPT code 0352U

Multiplex amplified probe test for detecting bacterial vaginosis-associated bacteria and Candida species in vaginal fluid.

Report only one unit per specimen analyzed on a single date of service.Use only for Xpert® Xpress MVP from Cepheid®.

Modifiers may apply depending on the place of service and other factors. Consult your payer's guidelines.

Medical necessity is established based on the patient's clinical presentation (symptoms) suggestive of bacterial vaginosis or vaginitis. The test is considered medically necessary to guide appropriate antimicrobial therapy and manage the infection.

Laboratory personnel perform the test using Cepheid's GeneXpert instrument. The clinician interprets the results and determines the appropriate treatment plan based on the detected organisms.

IMPORTANT:This PLA code (0352U) supersedes similar Category I codes such as 81514 and should not be reported with other CPT codes, including specific infectious agent detection codes like 87480, 87481, 87482, 87660, or 87661.

In simple words: This lab test checks a vaginal sample for bacteria and yeast that can cause infections.It uses a special technique to identify specific types of bacteria and yeast, giving a "yes" or "no" result for each.

This CPT code 0352U represents a proprietary laboratory analysis (PLA) for the detection of bacterial vaginosis-associated bacteria (BVAB-2, Atopobium vaginae, and Megasphera type 1) and multiple Candida species (C. albicans, C. tropicalis, C. parapsilosis, C. dubliniensis, Candida glabrata/Candida krusei) and Trichomonas vaginalis in a vaginal fluid specimen using a multiplex amplified probe technique.The test employs an algorithmic analysis to report findings as "detected" or "not detected" for each organism.The analysis includes DNA extraction, polymerase chain reaction (PCR) amplification, and detection using multiplex probes.

Example 1: A 28-year-old female presents with vaginal discharge, odor, and itching. The physician orders the Xpert® Xpress MVP test (0352U) to identify the causative agent., A 35-year-old female with a history of recurrent bacterial vaginosis is experiencing symptoms again.The physician uses the Xpert® Xpress MVP test (0352U) to guide treatment and monitor for recurrence., A 40-year-old female with abnormal vaginal bleeding undergoes a pelvic exam, and the physician orders the Xpert® Xpress MVP test (0352U) to rule out infection.

* Patient demographics and relevant clinical information.* Detailed description of patient's symptoms.* Specimen collection and handling documentation.* Lab report with detailed results, including identification of each detected organism and the date of service.

** This code is specific to the Xpert® Xpress MVP test from Cepheid®.The results are reported as detected or not detected for each organism, without quantification.

** Only Enterprise users with EHR integration can access case-specific answers. Click here to request access.

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