2025 CPT code 0374U
(Active) Effective Date: N/A Proprietary Laboratory Analyses Feed
Infectious agent detection by nucleic acid (DNA or RNA), genitourinary pathogens, identification of 21 bacterial and fungal organisms and identification of 21 associated antibiotic-resistance genes, multiplex amplified probe technique, urine.
Medical necessity for 0374U is established when a patient presents with signs and symptoms suggestive of a urogenital infection. This test is also medically necessary for screening in specific populations like pregnant women.
The clinician orders this test for patients with symptoms of a genitourinary infection. The test is performed on a urine specimen using an automated platform such as a Thermo Fisher Scientific Applied Biosystems QuantStudio Real-Time PCR System. The procedure includes DNA extraction, quantitative real-time polymerase chain reaction (qPCR) to amplify target genes, and detection of bacterial or fungal targets using nucleic acid probes for multiple organisms.
In simple words: This test helps diagnose and treat urinary tract infections by identifying 21 bacteria and fungi and 21 related antibiotic resistance genes from a urine sample. It provides faster results than traditional urine cultures, aiding in quicker diagnosis and treatment.
Urogenital Pathogen with Rx Panel (UPX) from Lab Genomics LLC, Thermo Fisher Scientific. This test evaluates a urine specimen using a multiplex amplified probe technique to detect 21 bacterial and fungal organisms and 21 associated antibiotic-resistance genes to aid in the diagnosis and treatment of urogenital infections.
Example 1: A 25-year-old female presents with dysuria, urinary frequency, and urgency. The physician orders a 0374U test to identify the causative organism and guide antibiotic treatment., A 60-year-old male with a history of recurrent UTIs presents with fever, chills, and flank pain. The 0374U test is ordered to quickly identify the pathogen and any antibiotic resistance, aiding in prompt and effective treatment., A 30-year-old pregnant woman with asymptomatic bacteriuria is screened using the 0374U test to ensure appropriate and timely antibiotic treatment, preventing potential complications.
Proper documentation for 0374U should include signs and symptoms of urogenital infection, patient demographics, date and time of specimen collection, ordering physician information, and the specific test name (Urogenital Pathogen with Rx Panel [UPX]).
** This code is specific to a proprietary test. It takes precedence over other CPT codes describing similar tests. Additional procedures like microdissection may be reported separately.
- Payment Status: Active
- Specialties:Urology, Infectious Disease, Family Medicine, Obstetrics and Gynecology
- Place of Service:Office, Inpatient Hospital, Outpatient Hospital, Independent Laboratory