BETA v.3.0

2025 CPT code 81163

BRCA1 and BRCA2 gene analysis; full sequence analysis.

This code includes all analytical services performed in the test, from cell lysis to detection. Procedures before cell lysis, such as microdissection, are reported separately. Modifier 26 can be used if only interpretation and report are performed by a physician.

Medical necessity is established by the presence of risk factors for BRCA-related cancers, including personal or family history of breast, ovarian, prostate, or other related cancers, or clinical findings suggestive of a hereditary cancer syndrome.

In simple words: This test analyzes the entire gene sequence of BRCA1 and BRCA2 genes to identify harmful changes that increase the risk of certain cancers, including breast, ovarian, prostate, and others. It uses a sample of your blood or saliva to examine your DNA.

BRCA1 (BRCA1, DNA repair associated), BRCA2 (BRCA2, DNA repair associated) (e.g., hereditary breast and ovarian cancer) gene analysis; full sequence analysis.

Example 1: A woman with a family history of breast and ovarian cancer seeks testing to understand her own risk., A man recently diagnosed with prostate cancer undergoes testing to determine if he has a hereditary predisposition and to inform treatment decisions and family screening., A patient with a known BRCA1 mutation has this test to confirm the presence of specific genetic variants and to inform personalized treatment strategies.

Detailed family history of cancer, particularly breast, ovarian, prostate, and pancreatic cancers. Patient consent for genetic testing. Documentation of the reason for testing, such as personal or family history of cancer or specific clinical findings.

  • Specialties:Genetics, Oncology
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