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BETA v.3.0

2025 CPT code 81173

Androgen receptor (AR) (e.g., spinal and bulbar muscular atrophy, Kennedy disease, X chromosome inactivation) gene analysis; full gene sequence.

This code includes all analytical steps involved in sequencing the AR gene. If additional procedures, like microdissection, are performed, they should be reported separately. When only the interpretation and report are performed, modifier 26 should be appended.

Modifier 26 can be used if only the professional component (interpretation and report) is performed.

Medical necessity is established by the presence of signs, symptoms, or a family history suggestive of a condition related to the AR gene, such as Kennedy disease or androgen insensitivity. The test should be ordered when the results will impact the patient's clinical management.

The laboratory professional performs the technical aspects of the test, including DNA extraction, amplification, and sequencing. A physician or other qualified healthcare professional typically interprets the results.

In simple words: This test analyzes the complete genetic code of the androgen receptor gene. It helps diagnose conditions like Kennedy disease, a genetic disorder causing muscle weakness, or to check for other genetic changes related to this gene.

This code represents the analysis of the entire androgen receptor (AR) gene sequence. This test is often used to diagnose Kennedy disease (spinal and bulbar muscular atrophy), an X-linked recessive disorder. It may also be used to assess for X chromosome inactivation or other conditions related to the AR gene.

Example 1: A male patient presents with progressive muscle weakness and atrophy, particularly in the bulbar muscles. The physician orders AR gene sequencing (81173) to confirm a diagnosis of Kennedy disease., A female carrier of Kennedy disease undergoes genetic testing to analyze the AR gene and assess the pattern of X chromosome inactivation. This helps determine the potential severity of the condition if passed on to male offspring., A patient presents with symptoms of androgen insensitivity. AR gene sequencing (81173) is performed to identify any mutations in the AR gene that could be causing the condition.

The documentation should include the reason for the test, relevant clinical findings, and family history if applicable. A signed order from the physician is also required.

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