2025 CPT code 81225
Effective Date: N/A Pathology and Laboratory Procedures - Molecular Pathology Procedures Feed
CYP2C19 (cytochrome P450, family 2, subfamily C, polypeptide 19) (e.g., drug metabolism), gene analysis, common variants (e.g., *2, *3, *4, *8, *17).
Modifier 26 may be appended if only the professional component (interpretation and report) is performed by the physician.
Medical necessity for 81225 is determined by the patient's clinical condition and the potential impact of the test results on medication selection and management. Certain ICD-10-CM codes might further support the medical necessity.
In simple words: This test analyzes your CYP2C19 gene for common variations that can impact how your body processes certain medications. Understanding these variations can help your doctor choose the right medication and dosage for you.
This code represents a molecular pathology procedure for the analysis of the CYP2C19 gene, focusing on common variants like *2, *3, *4, *8, and *17, which are known to affect drug metabolism. The procedure includes all analytical steps involved in testing for these variants.
Example 1: A patient with a history of adverse reactions to certain antidepressants is prescribed a new medication metabolized by CYP2C19. The 81225 test helps determine the patient's CYP2C19 genotype to guide medication selection and dosage., Before starting clopidogrel (Plavix), a patient undergoes 81225 testing to assess their CYP2C19 genotype. This helps predict their response to the drug and the risk of potential adverse events. , A patient with a family history of poor drug metabolism undergoes pharmacogenetic testing using 81225 to identify potential variations in the CYP2C19 gene, allowing for personalized medicine approaches.
Documentation should include the patient's medical history, family history of adverse drug reactions, and the specific medications for which the test is ordered. The rationale for ordering the test and its potential impact on treatment decisions should also be documented.
- Specialties:Cardiology, Oncology, Psychiatry, Clinical Pharmacology, Genetics
- Place of Service:Independent Laboratory, Office