2025 ICD-10-CM code D89.1
(Active) Effective Date: N/A Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism - Other disorders involving the immune mechanism, not elsewhere classified Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) Feed
Cryoglobulinemia is a condition characterized by the presence of cryoglobulins in the blood.
Medical necessity for treatment of cryoglobulinemia is established by the presence of signs and symptoms, confirmation of the diagnosis through laboratory testing, and the potential for complications if left untreated. The specific treatment approach should be justified based on the individual patient's presentation and the severity of their condition.
Clinicians diagnose cryoglobulinemia based on patient history, symptoms, physical examination, and laboratory tests such as CBC, serum chemistry, urinalysis, liver function tests, quantitative cryoglobulin test, antinuclear antibody test, ESR, complement fixation, and protein electrophoresis. Treatment varies depending on the type and severity of the condition and any underlying causes, and may include NSAIDs, antibiotics, immunosuppressants, plasmapheresis, and interferon therapy.
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
- Certain disorders involving the immune mechanism (D80-D89)
In simple words: Cryoglobulinemia is a disorder where abnormal proteins in your blood clump together in the cold, causing inflammation throughout your body.This can lead to various symptoms like skin discoloration, joint pain, and fatigue.
Cryoglobulinemia is an immune disorder characterized by the presence of cryoglobulins (immunoglobulins that precipitate at low temperatures) in the serum, leading to systemic inflammation. It can be classified as simple (type I) or mixed (type II or type III).
Example 1: A patient presents with bluish discoloration of the fingers and toes in cold weather, joint pain, and fatigue.Blood tests reveal the presence of cryoglobulins, confirming a diagnosis of cryoglobulinemia., A patient with chronic hepatitis C infection develops kidney problems and skin rashes. Further testing identifies cryoglobulins, indicating cryoglobulinemia secondary to hepatitis C., A patient experiences unexplained purpura, weakness, and numbness in the extremities.After extensive testing, including a cryoglobulin test, a diagnosis of mixed cryoglobulinemia is made.
Documentation should include details of the patient's signs and symptoms, medical history, relevant laboratory test results (CBC, serum chemistry, urinalysis, liver function tests, cryoglobulin test, etc.), and any underlying conditions.The type of cryoglobulinemia (if identified) should also be documented.
- Specialties:Hematology, Rheumatology, Immunology, Infectious Disease
- Place of Service:Inpatient Hospital, On Campus-Outpatient Hospital, Office