2025 CPT code 81272

KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (e.g., gastrointestinal stromal tumor [GIST], acute myeloid leukemia, melanoma), gene analysis, targeted sequence analysis (e.g., exons 8, 11, 13, 17, 18).

Any procedures prior to cell lysis (e.g., microdissection) should be reported separately. For physician interpretation and report only, use modifier 26.

Modifier 26 can be used if only the professional component (interpretation and report) is performed.

Medical necessity is established by the clinical indication for testing. The documentation should support the need for the test based on the patient's signs, symptoms, and clinical history.

The laboratory professional performs the technical aspects of the test. The results may require interpretation by a physician or other qualified healthcare professional (for which modifier 26 can be used with this code).

In simple words: This test analyzes specific parts of the KIT gene for changes that could be related to certain cancers and other diseases. It helps doctors figure out if these changes are present and might be causing problems.

This code represents a targeted sequence analysis of the KIT gene, focusing on specific exons (8, 11, 13, 17, and 18). It includes all analytical steps involved in the process, from cell lysis and nucleic acid stabilization to amplification and detection. The KIT gene plays a crucial role in cell growth, division, and survival, and variations in these specific exons can be indicative of certain conditions such as gastrointestinal stromal tumors (GISTs), acute myeloid leukemia, and melanoma.

Example 1: A patient with suspected GIST undergoes this test to confirm the diagnosis and guide treatment., A patient with acute myeloid leukemia is tested to identify specific KIT mutations that could impact prognosis and treatment strategy., This test is used to assess for KIT mutations in patients with melanoma to determine eligibility for targeted therapies.

Documentation should include the reason for testing, relevant clinical findings, and the specific exons analyzed.

  • Specialties:Pathology, Oncology, Hematology, Genetics
  • Place of Service:Independent Laboratory, Hospital Outpatient, Office
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