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2025 CPT code 81372

HLA Class I typing, low resolution (e.g., antigen equivalents); complete (i.e., HLA-A, -B, and -C)

The code is specifically for low-resolution typing of Class I HLA loci (A, B, and C). Use other codes for Class II typing (81375), higher-resolution typing (81371, 81373-81377), or when typing both Class I and Class II (81370).

Modifier 26 may be appended if only the interpretation and report are provided by the physician/qualified healthcare professional.

Medical necessity for this test is established when the information is required for transplantation or diagnosis/management of disease.

In simple words: This test identifies specific genetic markers (HLA types) on your white blood cells that are important for determining compatibility in organ or stem cell transplants.It's like checking if your blood type is A, B, or O, but much more detailed within a specific group of markers (HLA Class I).This test looks at three of these specific markers (HLA-A, HLA-B, HLA-C) at a general level of detail.

This code represents the laboratory testing for Human Leukocyte Antigen (HLA) Class I typing at low resolution, covering HLA-A, -B, and -C loci using molecular techniques.It includes all analytical steps involved in the process, from cell lysis and nucleic acid extraction to identifying the specific HLA gene sequences through methods like amplification, hybridization with nucleic acid probes, or direct sequencing-based typing. Low resolution typing means identifying alleles without high specificity, such as at the two-digit level or broader classifications.

Example 1: A patient is being evaluated as a potential kidney transplant recipient. HLA typing is performed to determine the patient's tissue type and match it with potential donors., A patient with leukemia is undergoing a search for a matching stem cell donor. HLA typing of the patient and potential donors is essential for finding the best possible match., A physician suspects an autoimmune disease in a patient.HLA typing is performed because certain HLA types are associated with a higher risk of developing specific autoimmune disorders.

Documentation should include the reason for the HLA typing (e.g., transplant evaluation, autoimmune disease diagnosis), the patient's relevant medical history, and the interpretation of the test results.

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