In simple words: CVID is a disorder where the body's immune system doesn't produce enough antibodies, making it difficult to fight off infections.People with CVID get sick often, especially with respiratory infections. They may also have digestive problems and an increased risk of autoimmune diseases and certain cancers.

Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder characterized by low levels of serum immunoglobulins (IgG, IgA, and sometimes IgM), leading to an increased susceptibility to infections, particularly bacterial infections of the respiratory tract, ears, and sinuses.The condition may be associated with autoimmune disorders, gastrointestinal problems, granulomas, and an increased risk of certain cancers. CVID is a heterogeneous disorder with variable clinical manifestations.

Example 1: A 30-year-old patient presents with recurrent pneumonia, sinusitis, and bronchitis. Laboratory tests reveal significantly reduced IgG and IgA levels, confirming the diagnosis of CVID., A child experiences repeated ear infections and diarrhea. After extensive testing, including immunoglobulin levels and genetic analysis, the child is diagnosed with CVID., A patient with rheumatoid arthritis and a history of recurrent respiratory infections is found to have low immunoglobulin levels, indicating a diagnosis of CVID with an autoimmune complication.

Documentation should include evidence of recurrent infections, low serum immunoglobulin levels (IgG, IgA, and IgM), and any associated conditions such as autoimmune disorders, gastrointestinal issues, granulomas, or malignancies.Specific tests performed and their results should be documented.