2025 CPT code 0437U
(New) Effective Date: N/A Laboratory - Multianalyte assays with algorithmic analyses (MAAA) Proprietary Laboratory Analyses Feed
This CPT code reports the MindX One™ Blood Test — Anxiety, a proprietary laboratory analysis (PLA) using gene expression profiling of 15 genes to provide a predictive risk score for anxiety disorders.
Modifiers may apply depending on the circumstances of service. Consult the CPT manual and payer guidelines for appropriate modifier use.
Medical necessity for this test is established when the physician requires a predictive risk score for anxiety to assist with diagnosis and to guide treatment decisions. The test is supported by the clinical presentation and the need for objective data to personalize patient care.Justification should include details of the patient’s symptoms and why this test is needed to inform treatment decisions.
The clinical responsibility involves ordering the test to aid in the diagnosis of anxiety disorders and monitoring treatment response. The laboratory's responsibility is to perform the analysis, including RNA extraction, amplification, microarray analysis, and bioinformatics to produce a predictive risk score and treatment suggestions.
In simple words: This lab test (MindX One™ Blood Test — Anxiety) uses a blood sample to predict your risk of having an anxiety disorder. It looks at specific genes and uses a computer program to calculate a score. This score can help doctors determine if you need treatment and what kind of treatment might be most helpful.
CPT code 0437U is a Proprietary Laboratory Analysis (PLA) code for the MindX One™ Blood Test — Anxiety, offered by MindX Sciences.This test employs gene expression profiling of 15 biomarkers via mRNA sequencing from a whole blood specimen.The results are algorithmically analyzed to generate a predictive risk score for anxiety disorders, along with insights into potential treatment options. The analysis includes RNA extraction, amplification, and microarray technology to identify and quantify expressed genes. Bioinformatics is used to calculate the risk score and suggest treatment strategies.The test's objective is to assist in diagnosing anxiety disorders and guiding treatment.
Example 1: A patient presents with symptoms suggestive of generalized anxiety disorder. The physician orders the MindX One™ Blood Test — Anxiety (0437U) to aid in diagnosis and to guide the selection of appropriate anxiolytic medication., A patient diagnosed with anxiety disorder is undergoing treatment but is not experiencing satisfactory improvement.The physician orders the MindX One™ Blood Test — Anxiety (0437U) to assess response to current treatment and consider adjustments., A research study is investigating the effectiveness of a new anxiolytic medication.Researchers utilize the MindX One™ Blood Test — Anxiety (0437U) to stratify participants based on their predicted risk of anxiety disorders before and after treatment.
* Patient demographics and clinical history, including presenting symptoms and current medications.* Properly collected and labeled whole blood specimen.* Physician's order specifying the MindX One™ Blood Test — Anxiety.* Complete laboratory report including the calculated risk score, identified biomarkers and treatment suggestions.
** The accuracy of this PLA code is maintained by the original applicant or the current owner of the test. A new PLA code is required if additional analysis is added or the test name changes.
- Revenue Code: T1G (LAB TESTS - OTHER)
- Payment Status: Active
- Modifier TC rule: Not applicable for this specific PLA code.
- Specialties:Psychiatry, Clinical Psychology
- Place of Service:Office, Hospital Outpatient, Clinical Laboratory