2025 CPT code 81183
(Active) Effective Date: N/A Revision Date: N/A Laboratory - Molecular Pathology Procedures Pathology and Laboratory Procedures Feed
Analysis of the ATXN10 gene to detect abnormal alleles, particularly expanded sequences.
Modifiers may be appended to this code to indicate specific circumstances. For instance, modifier 26 may be added if only the professional interpretation is performed; other modifiers might apply based on specific circumstances or payer guidelines.
Medical necessity for this test is typically established when a patient presents with clinical features suggestive of SCA10 or when family history warrants carrier testing.The test aids in diagnosis and genetic counseling.
The clinical responsibility lies primarily with the laboratory personnel who perform the technical aspects of the test, including nucleic acid extraction, amplification, and detection. A physician or other qualified healthcare professional may interpret the results and generate a report; this is usually billed separately.
In simple words: This lab test checks for changes in the ATXN10 gene.It looks for extra-long sections of repeated DNA, which can cause problems. The test uses a blood sample and involves several steps to find these changes.
This CPT code encompasses the technical component of analyzing the ataxin 10 gene (ATXN10) to identify abnormal alleles, primarily focusing on expanded sequences.The procedure involves multiple analytical steps: nucleic acid extraction (e.g., through cell lysis and digestion), amplification (e.g., via polymerase chain reaction, PCR), and detection of the target gene.The results may be interpreted by a qualified healthcare professional (physician or other), and this interpretation service is reported separately using modifier 26 if applicable.
Example 1: A patient presents with symptoms suggestive of spinocerebellar ataxia type 10 (SCA10).The physician orders this test to confirm the diagnosis by identifying expanded alleles in the ATXN10 gene. , Genetic testing is performed on a family member of an individual diagnosed with SCA10 to assess their carrier status for the ATXN10 gene mutation., A research study is investigating the role of ATXN10 gene variations in the development of other neurological disorders. The test is used to analyze gene samples for a large cohort of participants to examine any correlations.
The requisition should clearly indicate the patient's clinical information, including symptoms, family history of SCA10, and reason for ordering the test. The laboratory report should include detailed information about the methodology used, results (including the number of ATTCT repeats), and interpretation of findings.
** Further details on the specific methodology employed in the analysis (e.g., type of PCR used) may be necessary for accurate coding and reimbursement in certain instances. Always verify with the relevant payer and refer to the most up-to-date CPT coding guidelines.
- Payment Status: Active
- Modifier TC rule: The technical component (TC) is considered the primary portion of this test, so modifier TC is not typically used. However, consult payer guidelines to ensure consistent practices.
- Fee Schedule: Information about historical fee schedules is unavailable. This information varies by payer and geographic location. Please check with the relevant payer for information pertaining to your location and the historical fee schedules.
- Specialties:Neurology, Medical Genetics, Clinical Pathology
- Place of Service:Office, Hospital, Laboratory