2025 CPT code 81342
(Active) Effective Date: N/A Revision Date: N/A Laboratory - Molecular Pathology Procedures Pathology and Laboratory Feed
Analysis of T-cell receptor gamma (TRG) gene rearrangements to detect abnormal clonal T-cell populations, which may indicate leukemia or lymphoma.
Modifier 26 may be appended if only the interpretation and report are performed.
Medical necessity for 81342 is established based on the presence of clinical symptoms or findings suggestive of a clonal T-cell disorder, such as those seen in leukemia or lymphoma.The test helps diagnose and monitor these conditions.The ordering physician should document the clinical rationale for ordering the test.
The clinical responsibility lies with the laboratory analyst who performs all technical aspects of the test, from nucleic acid extraction and amplification to detection of target genes.A physician or other qualified healthcare professional may interpret the results.
In simple words: This lab test looks for abnormal changes in a specific gene (TRG) within T-cells. These changes can be a sign of certain types of blood cancers like leukemia and lymphoma.
This CPT code encompasses the analytical procedures involved in the examination of T-cell receptor gamma (TRG) gene rearrangements to identify abnormal clonal T-cell populations.The procedure includes nucleic acid extraction (e.g., cell lysis, digestion), amplification to increase the quantity of nucleic acid for analysis, and detection of target genes using techniques such as nucleic acid probes. The analysis aims to detect clonal T-cell populations, indicative of certain leukemias and lymphomas.Results may require interpretation by a qualified healthcare professional (modifier 26 may be appended if only interpretation is performed).
Example 1: A patient presents with symptoms suggestive of T-cell acute lymphoblastic leukemia (T-ALL).A bone marrow sample is sent to the lab for 81342 testing to assess for clonal T-cell populations., A patient with a history of lymphoma undergoes follow-up testing, including 81342, to monitor for disease recurrence or response to therapy.Peripheral blood is used for the analysis., A patient with unexplained lymphocytosis (elevated lymphocyte count) undergoes 81342 testing to evaluate for the possibility of a clonal T-cell disorder.
* Patient demographics and relevant clinical history.* Specimen type (e.g., bone marrow aspirate, peripheral blood).* Indication for testing (e.g., suspected leukemia/lymphoma, follow-up).* Complete lab report including results and interpretation.
- Payment Status: Active
- Specialties:Hematology, Oncology, Pathology
- Place of Service:Laboratory