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2025 CPT code 81373

Low-resolution HLA Class I typing for one locus (HLA-A, -B, or -C).

Refer to CPT guidelines for Molecular Pathology Procedures.If only interpretation is performed, modifier 26 may be appended.Prior procedures (e.g., microdissection) should be reported separately.

Modifiers 26 (professional component), 59 (distinct procedural service), 90 (reference laboratory), 91 (repeat test), and potentially others depending on the specific scenario, may be applicable.

Medical necessity is established based on the clinical indication, such as organ or stem cell transplant compatibility assessment, or investigation of HLA-associated diseases.Documentation must support the need for the test.

The clinical responsibility lies with the laboratory analyst who performs all technical aspects of the test, from nucleic acid extraction to identifying target HLA gene sequences.

IMPORTANT Use code 81372 for complete Class I (HLA-A, -B, and -C) low-resolution HLA typing. Use code 81374 when low-resolution testing reports the presence or absence of a single antigen equivalent.For serological HLA Class I typing, use codes 86812-86821. If more than one, but not all, Class I loci are tested, report one unit of 81373 for each locus.

In simple words: This lab test identifies a specific gene (HLA) related to the immune system at a low or intermediate level of detail. This helps determine compatibility for organ or stem cell transplants or to identify genes related to certain diseases.

This CPT code encompasses the technical component of low or intermediate-resolution Human Leukocyte Antigen (HLA) Class I typing using molecular techniques.It involves identifying specific alleles at one HLA Class I locus (HLA-A, -B, or -C).The typing is not high-resolution; it may identify alleles without high specificity. The procedure includes all analytical services such as cell lysis, nucleic acid extraction, amplification, and detection.

Example 1: A patient is undergoing a bone marrow transplant.HLA typing is performed to assess compatibility between the donor and recipient., A patient presents with symptoms suggestive of an HLA-associated disease. HLA typing is performed to identify a specific HLA allele that could be linked to the condition., A patient needs solid organ transplant. HLA typing is performed to determine compatibility with a potential donor.

Detailed patient history, including reason for testing,method of sample collection and processing, results of the HLA typing, and interpretation (if performed separately).

** The code 81373 applies to low or intermediate resolution HLA typing.High-resolution typing would require a different code.Always refer to the most up-to-date CPT codebook and guidelines for accurate coding.

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