In simple words: This test examines specific genes called HLA genes that help your body's immune system recognize its own cells. It's often used before transplants to see how well a donor and recipient match, or to check for genes linked to certain diseases.The test focuses on a small part of these genes, giving a general idea of their makeup rather than a very detailed picture.

This code represents the laboratory testing for Human Leukocyte Antigen (HLA) Class II typing at low or intermediate resolution for a single locus using molecular techniques.The procedure includes all analytical steps involved in the test, starting from nucleic acid extraction (e.g., cell lysis, digestion) to identification of the target HLA gene sequences (e.g., amplification, hybridization with nucleic acid probes, or direct sequencing-based typing). The resolution of typing identifies alleles without high specificity, such as to the two-digit HLA name, or using broader classifications like a string of alleles or a National Bone Marrow Donor Program code. Examples of Class II loci include HLA-DRB1, -DRB3/4/5, -DQB1, -DQA1, -DPB1, or -DPA1. While not restricted to specific conditions, this test is often used for assessing donor/recipient compatibility in solid organ or hematopoietic stem cell transplants, or for identifying HLA Class II alleles associated with particular disease states.

Example 1: A patient awaiting a kidney transplant needs HLA typing to assess compatibility with potential donors., A patient with a suspected autoimmune disease undergoes HLA typing to check for the presence of specific alleles associated with the condition., A patient requires a bone marrow transplant, necessitating HLA typing for donor matching.

Documentation should include the reason for testing (e.g., transplant, disease diagnosis), the specific locus tested, and the resolution of typing performed (low or intermediate). The report should clearly identify the alleles present.