2025 CPT code 81380
(Active) Effective Date: N/A HLA Typing - Molecular Pathology Procedures Pathology and Laboratory Feed
HLA Class I typing, high resolution (ie, alleles or allele groups); one locus (eg, HLA-A, -B, or -C), each.
Modifier 26 may be appended if only the professional component (interpretation and report) is performed by the physician.
Medical necessity is determined by the clinical indication for the test.Transplantation requires HLA matching for optimal outcomes.Certain diseases are linked to specific HLA alleles, making testing necessary for diagnosis or prognosis. The documentation must support the medical necessity for HLA typing.
The laboratory analyst performs all technical aspects of the test, from nucleic acid extraction to identification of target gene sequences.
In simple words: This test analyzes specific genes related to the body's immune system. It helps determine the type of proteins (HLA) on the surface of cells, used to distinguish the body's own cells from foreign ones. This detailed analysis focuses on one specific gene location (locus) related to HLA Class I, providing high-resolution results.This test is often used to match donors and recipients for organ or stem cell transplants, or to diagnose certain diseases.
High-resolution HLA Class I typing for a single locus (HLA-A, -B, or -C) using molecular techniques.This involves identifying specific alleles or allele groups with high specificity, often to a 4-digit resolution for common alleles.For rare alleles, the result may be a string of alleles or a National Marrow Donor Program code. Includes all analytical steps from cell lysis to identification of the target gene sequences via amplification and hybridization or direct sequencing. Note: For complete Class I typing of HLA-A, -B, and -C, use 81379. For presence/absence of a single allele/group at high resolution, use 81381.
Example 1: A patient awaiting a kidney transplant needs HLA typing to assess compatibility with potential donors., A patient with a suspected autoimmune disease requires HLA typing to identify specific alleles associated with the condition., A patient being evaluated for a bone marrow transplant needs high-resolution HLA typing to match with a suitable donor.
Documentation should include the reason for testing (e.g., transplant, disease diagnosis), the specific locus tested (HLA-A, -B, or -C), and the methodology used (molecular typing). Any preparatory procedures (e.g., microdissection) should also be documented.
- Specialties:Pathology, Immunology, Hematology/Oncology, Transplantation
- Place of Service:Independent Laboratory, Hospital Outpatient